ABSTRACT
How to reduce immune response is an unprecedented challenge for rAAV gene medicine. Recent studies suggested that lowering dosage of the vector used could reduce immune response caused by rAAV gene medicine. Nevertheless, it would also decrease the transgene expression, leading to failure of gene treatment. It is therefore important to take appropriate steps to maintain high gene expression level and pharmacodynamic, while the dosage of rAAV used is reduced. Here, steps to enhancing gene therapy, such as optimization of the administration, reconstruction of the viral vector and selection of the promoter, are discussed in order to achieve maximum outcome.
ABSTRACT
OBJECTIVE To investigate inspection report sheets preserving type and hand hygiene behavior among patients,and to discuss countermeasures to ensure medical safety for patients. METHODS Random sampling investigation was carried out between one experimental group,whose members were general clinic patients,and one control group,whose members were physical examinees for employment. Statistical analysis for the original data was taken by using SPSS software. RESULTS In the experimental group and in the control group respectively,the ratio of patients who had correct cognition on the biosafety of inspection report sheet was 66.90% and 78.72%,80.80% and 94.86% patients washed hands after touching inspection report sheets,71.00% and 87.00% patients suggested that biosafety label be tagged on the inspection report and hand washing facilities be supplied in the hospital. CONCLUSIONS The hospital is responsible to popularize the knowledge about hand hygiene behavior and hospital infection education,to append specific hand washing facilities,and to improve the patients' understanding of biosafety and hand washing compliance.